A tuned affinity-based staurosporine probe for in situ profiling of protein kinases.
نویسندگان
چکیده
A clickable and cell-permeable affinity-based probe (AfBP) was designed from staurosporine, by incorporating an electrophilic chloroacetamide warhead to facilitate in situ proteome labeling of a range of potential kinase targets.
منابع مشابه
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.
A clickable, affinity-based probe (AfBP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 22 شماره
صفحات -
تاریخ انتشار 2014